There are problems of storage pressure, calculation delay and cloud side communication caused by a large number of multi-dimensional heterogeneous power grid data. Therefore a cloud edge collaborative control method of reactive power and voltage in a distribution network based on Edgex Foundry is proposed. First, this paper obtains the power grid data on the 10 kV side of the distribution network, builds a collaborative control module for “edge cloud” and “edge” and a reactive power and voltage information interaction model of the distribution network. It establishes a cloud edge data transmission channel based on multi protocols. Second, the cloud edge collaborative control model oriented to distribution network reactive power and voltage is deployed. The "cloud edge end" centralized distributed collaborative control architecture for distribution network reactive power and voltage based on Edgex Foundry is constructed. This implements interactive integration of cloud edge collaborative architecture and a fifteen zone map control strategy. Finally, based on simulation verification, the proposed control method can reduce computational latency, alleviate cloud computing and storage pressure, and achieve deep integration of two control modes in cloud edge collaborative control: the connection of the bus and branch line and the local monotony of the abnormal branch line. This provides technical support for realizing the cloud edge collaborative control of reactive power and voltage in distribution networks.