A new energy grid tie-line zero-sequence directional pilot protection setting method is proposed. Considering various connection groups of main transformers in new energy stations, including YNd, YNdd, YNynd connection types, the expressions of zero-sequence measured impedance on both sides of the line are derived when ground faults occur inside and outside the grid tie-line. The results show that the zero-sequence measurement impedance of the new energy station side of the main transformer with YNd, YNdd connection types is related to the main transformer connection group when the grounding fault occurs in the grid tie-line area. The YNynd connection type is related to the main transformer connection group and the system operation mode. Based on the results, the setting method of the maximum sensitive angle and action zone of the zero-sequence positive and negative directional elements of the new energy grid tie-line is given. PSCAD/EMTDC simulation results show that the zero-sequence impedance angle is consistent with the analysis conclusion in various fault conditions, and the zero-sequence directional pilot protection can operate correctly.