To improve the efficiency and correctness of intelligent operation and maintenance information collection and configuration of relay protection, this paper proposes a self-configuration technology based on a knowledge graph. Based on the relevant specifications of relay protection, a standardized model of the data output port of the relay protection device is established, and according to expert knowledge, the relationship between the information collection point of the intelligent operation and maintenance system and the standardized data output port of the relay protection device is established according to the type of IED. Then the knowledge map ontology of the information collection and configuration of the intelligent operation and maintenance system is formed. Combined with the historical configuration data for knowledge learning, a knowledge map of information collection and configuration is established. Based on the similarity calculation between the address information of the data output port of the secondary equipment and the standard model of the data output port of the relay protection device, the data output port of the secondary equipment is automatically matched to the standard information interface to realize knowledge fusion. A CBOW model is introduced to enhance semantic understanding and improve the accuracy of entity similarity algorithm. The example verification results show that the information collection and self-configuration technology of the intelligent operation and maintenance system based on a knowledge graph can effectively improve the configuration efficiency and ensure the correctness of the configuration. This work is supported by the National Natural Science Foundation of China (No. 51277135).