Firstly, based on the analysis of the current situation that the power monitoring system cannot support the substation remote operation and maintenance and the “operation and maintenance integration” mode, this paper puts forward the necessity of constructing the regional operation and maintenance center. Then, a substation remote operation and maintenance architecture scheme with a two-layer architecture in the regional station domain is proposed. Under this architecture, based on the service requirements of substation intelligent device operation and maintenance, a three-tier application function deployment scheme of station end, regional end and operation and maintenance class terminal is presented. After that, based on the service-oriented regional station domain interaction framework, the station domain service interface scheme is designed in detail. Finally, the remote operation and maintenance services such as remote monitoring of equipment status, remote patrol, remote fault processing and remote intelligent diagnosis are realized by using distributed service processing between the regional domain and the station domain. The application practice shows that the application of substation intelligent device remote operation and maintenance platform improves the automation degree of equipment and system defect early warning and fault location, reduces the number of on-site inspection of device, and decreases the operation and maintenance cost. This work is supported by Science and Technology Project of State Grid Corporation of China (No. DZN17201700055) “Research and Application of Regional/Station Domain Intelligent Equipment Visible Operation and Maintenance Management Platform”.