In order to analyze on the adaptability of the large-capacity grid-connected PV station, this paper takes the hundred-billion grade project in Mangya for example. According to the maximum and minimum load operation data of Mangya, the power flow, bus voltage fluctuation, and N-1 security are simulated by using DIgSILENT/Power Factory software. According to the guideline, the adaptability of large-scale grid-connected PV station is studied and analyzed. The compensation method is proposed to improve the phenomena that the bus voltage drop amplitude is too large when large-scale PV grid connection. The adaptability of large-scale grid-connected PV station is improved. The analysis provides a reference for other engineering. This work is supported by Scientific and Technological Projects of Henan Province (No. 182102210112 and No. 172102210076).