Aiming at the status that the reliability and intelligence of power protection alteration scheme design needs to be improved, an intelligent anti-misoperation algorithm based on Petri net theory is put forward to verify a power protection alteration scheme automatically. The first step is to implement topological analysis for grid basic data, then the operating regulation is described based on methods of stratification and classification. The anti-misoperation method of power protection alteration schemes is built by the Petri net theory model which is based on the corpus topology and experts knowledge base. The practical operating shows that the anti-misoperation algorithm for power protection alteration scheme based on Petri net theory has the ability to provide accurate and abundant verification results, which therefore ensure the accuracy and security of the power protection alteration scheme. This work is supported by Science and Technology Project of State Grid Corporation of China (No. 5212001500LB).