More and more electric vehicle charging facilities are connected to the power grid now, and the harmonic pollution caused by the charging facilities under different charging modes will exert different effects on the power grid. This paper researches the Simulink simulation and harmonic analysis of the mutual influence between different charging modes charger in the charging station. Firstly, the simulation model of the electric vehicle power battery is established. Secondly, the simulation model of the electric vehicle charger under different charging modes is established. Thirdly, the power battery charging curve by simulation is equivalent to time-varying resistance, and it is input as a continuous signal to the charger model for simulation. Finally, different charging modes in different charging scenes are simulated, and harmonic mutual influence law of different charging modes charger on working is analyzed. This work is supported by Guizhou Science and Technology Foundation (No. J[2012]2157).