To avoid bus voltage conducting above the up limit for lack of compensation devices during light load periods, a new voltage regulation method based on 110 kV urban distribution network reconfiguration is introduced. The strategy takes example by medium voltage network reconfiguration and considers the restraint of line thermal stability, transformer capacity and switching power flow on boundary, through changing original 110 kV substation connection mode, finally optimizes the network voltage deviation degree. Contribution rate index is used to assess the influence of related substations’ different connection mode on network-wide voltage amplitude, and according to the calculated results, the grid connection modes are regulated, thus classic heuristic algorithm’s specific disadvantages of slow convergence speed and curse of dimensionality are avoided. Practical urban grid of Sichuan province indicates that the introduced voltage regulation method is simple and available, and can greatly optimize the voltage profile of the total network, so it has bright applying foreground in engineering.